![]() ![]() ![]() backwards through the available completions. ![]() insert mode, with at least one non whitespace character before the cursor, to. Excipient variability and feeding set-up are therefore two factors to be considered when optimizing feeding consistency. Using Supertab is as easy as hitting or (shift+tab) while in.However, for a stretched feeder set-up with 11 mm double concave screws rotating at 514 rpm, variability in material properties introduces additional variation in the obtained feed factor. Results show that for an optimized feeder set-up with 22 mm double concave screws rotating at 342 rpm, the batch-to-batch variation was negligible compared to the natural feeding variability. Both SuperTab 11SD and 14SD are made in a dedicated pharmaceutical lactose plant in Nrten-Hardenberg, Germany, and SuperTab 11SD is additionally made in Kapuni. It demonstrates the same free flow properties and excellent content uniformity properties as SuperTab® 11SD, but adds more compactability by an increased surface area. For the first time, over 200 batches were evaluated regarding the impact of batch-to-batch variability upon feeding performance in volumetric mode. SuperTab® 14SD is a spray dried monohydrate lactose particularly developed for improved compactability. Spray dried lactose SuperTab 11SD was selected as a material, as it is one of the most widely used filler-binders for direct compression of tablets and can make up to 70% of the tablet content. In this paper, it is investigated how and to what extent variability of lactose can impact the feeding performance in different feeder set-ups. The performance of feeders defines the content of components that are fed into the system and therefore the composition that ends up in the formulation. SuperTab11SD, a commercial available spray- dried lactose (SDL) was used as a benchmark for tabletability study only because lactose is a sugar alcohol and. Feeding is the first unit of operation in a continuous manufacturing line and is critical for the final product quality. SuperTab® 11SD Efficient processing through flow SuperTab® 11SD is a highly consistent, spray-dried monohydrate lactose enabling efficient tableting by offering free flow properties. With the emergence of quality by design (QbD), it becomes imperative to gain understanding of the impact of batch-to-batch variability of raw materials on the performance of processes. ![]()
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